Ensuring Drug Quality

Innovations
CZ

Shedding light on your medications

The Problem
At this time, drug testing technology for drug quality and active ingredient quantity is limited. It has been estimated that anywhere from 30-50% of available medications are of low quality or counterfeit (LQ/C) in countries with failed governance and conflict areas (LIC/FGC). LQ/C medications are a serious clinical problem and of increasing public health concern.

36 distinct technologies have been described but none meet the needs for point of care
testing in an LIC/FGC environment. A low-cost tool with high sensitivity and specificity that requires little training and uses local available reagents is still needed.

The Solution
We developed a point of care tool using properties of light spectroscopy to determine authenticity and quality of medications.

Methodology
We designed a tool that recognizes the “fingerprint” of each pharmaceutical compound when light is transmitted through an authentic sample at wavelengths in the ultraviolet (UV) light spectrum. This is the wavelength where the active pharmaceutical compound is reactive to light and is called the Baseline Spectral Fingerprint (BSF). We then leveraged the BSF through comparative assessment to infer quality of any random field sample and developed an algorithm to compensate for the randomness of field preparation using local sourced reagents.

We tested 125 samples of random substances prepared by a third party clinical pharmacologist. 20 were authentic samples while the remainder were prepared so that each sample was visually indistinguishable from the authentic samples but were either counterfeit or low quality (right medication, wrong concentration). The results yielded 1 false negative and 0 false positives. 

Next Steps
[What is currently being done? What are next steps?]

Learn how to get involved here.

Close Menu